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WE ARE CURRENTLY STILL RECRUITING FOR INDUSTRIAL COLLABORATIVE STUDENTSHIPS.


For more information click 'Apply for industrial CASE studentships' below



This 4-year programme is aimed at graduates with a strong interest in multi-disciplinary research. We invite applications from highly motivated students from a wide range of academic backgrounds including biological, biomedical, veterinary, physical, computational, engineering or mathematical disciplines.

 



This 4-year programme is aimed at graduates with a strong interest in multi-disciplinary research. We invite applications from highly motivated students from a wide range of academic backgrounds including biological, biomedical, veterinary, physical, computational, engineering or mathematical disciplines.



Please ensure that you read the Guidelines before submitting an application.

Your application and supporting documents should be sent in a single email to LIDo.Admissions@ucl.ac.uk
Your application must be complete, including both references, by the deadline of 11th January. To ensure sufficient time to contact your referees it is highly recommended that you submit your application a minimum of 1 week before this date.

Download the APPLICATION GUIDELINES here.

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Download BOTH sections of the Application Form here:
SECTION A
SECTION B
Or as a single APPLICATION FORM (ZIP FILE)

Students who wish to apply for an iCASE project (please see below), should also return the relevant form indicating their project preference.



Your application and supporting documents should be sent in a single email to LIDo.Admissions@ucl.ac.uk Your application must be complete, including both references, by the deadline of 2nd May at 5pm. To ensure sufficient time to contact your referees it is highly recommended that you submit your application a minimum of 1 week before this date.

PLEASE ENSURE TO STATE CLEARLY WHICH PROJECT YOU ARE APPLYING FOR

Download the APPLICATION GUIDELINES here.

Download BOTH sections of the Application Form here:
SECTION A
SECTION B
Or as a single APPLICATION FORM (ZIP FILE)

  • Understanding the mechanisms of epidermal barrier damage and repair using 3D skin equivalent models

    Supervisors:
    Dr. John Connelly, Reader in Bioengineering, Queen Mary University of London;
    Dr. Nidhin Raj, Sr. Innovation Scientist, Oral and Skin Health Group GSK.

    The epidermis of the skin provides an essential barrier between our bodies and the external environment through the formation of a dense cornified layer of cross-linked proteins and lipids at the surface of the skin. Chemical insult or impaired lipid synthesis can damage the cornified layer and lead to barrier dysfunction; however the fundamental relationships between lipid content and barrier biophysical properties remains poorly defined. In addition, there is a need for improved human-based experimental models for investigating lipid function and barrier repair in vitro, and for the evaluation of new therapeutic compounds.
    The aim of this PhD studentship is to develop a 3D organotypic skin model of impaired lipid synthesis in order to dissect the functional relationships between lipid synthesis, barrier mechanics, and tissue repair. In addition, this platform will be used to evaluate lipid mimetic compounds developed by the GSK Skin Health group. The project will employ shRNA to stably knockdown key enzymes involved in lipid biosynthesis and advanced biophysical methods to characterise the effects of impaired lipid synthesis and the response to lipid-mimetic treatments on skin barrier function. The project will consist of three major objectives.

    1. Build and characterise 3D skin models of impaired lipid synthesis.
    2. Develop quantitative relationships between lipid content and epidermal mechanics through lipidomic profiling and biophysical methods.
    3. Assess the effects of different lipid-based compounds on the biophysical properties and cellular functions within the model system. The successful completion of this project will provide fundamental insights in the mechanistic relationships between lipid content and epidermal barrier function. These findings will have a significant impact on our understanding of normal skin function and the consequences of lipid deficiencies. Importantly, this new knowledge could help identify new therapeutic targets for the treatment and repair of skin barrier damage.

  • Investigating erosion and abrasion on natural enamel

    Supervisors:
    Professor David Bartlett, King's College London
    Saoirse O’Toole, Unilever

    Erosive toothwear is the fourth most common dental condition, affecting up to 30% of European adults. Factors impacting erosive toothwear include acid exposure frequency (e.g. diet or stomach acid reflux) and abrasive factors (e.g. brush, tongue). Prevention of the condition on enamel is key to the control without which the condition can affect the whole dentition and potentially cost between £5000-£30,000 to restore. Little is known about the protective effects of pellicle, a salivary protein layer that naturally forms on the tooth surface, and how this can be modified to enhance protection of enamel from acid and abrasive factors. In addition, the role of enamel remineralisation agents (e.g. fluoride and calcium) on prevention of erosive toothwear processes is not well understood.
    This project follows a successful collaboration between Unilever Oral Care and the toothwear team at Kings. Together we have developed world beating science to measure erosive toothwear on complex topographical natural tooth surfaces. This unique skill creates laboratory models far superior to the conventional polished enamel surfaces. The next step in the development is to investigate how abrasion delivered by a toothbrush and toothpaste interacts with dietary acids on natural enamel, with or without salivary pellicle. The effect of differing times of acid exposure (matched to dietary acid concentration) to varying abrasivity of toothpastes and pressure applied to the brush will test the interaction between acids and abrasion. It is believed that this interaction is the main reason why erosive toothwear progresses, but the dynamics are unknown. In addition, the role of established remineralising agents in protecting and repairing the enamel surface is likely to be a factor in the overall erosion/abrasion process. Therefore, the impact of fluoride and calcium-based technologies on erosion/abrasion will be evaluated.



Applicants must hold, or be expected to achieve, a first or high upper second-class undergraduate honours degree or equivalent (for example BA, BSc, MSci) or a Masters degree in a relevant subject.

Applicants must be confident using computers and show some evidence of numeracy (minimum GCSE mathematics or statistics or an equivalent or alternatively a university degree module with a good grade).

All students whose first language is not English must be able to provide recent evidence that their spoken and written command of the English language is adequate for the programme. The required evidence may be one of the following:

  • Substantial education or work experience conducted in English
  • A recently obtained acceptable English language qualification or test result.Our preferred English language qualification is the International English Language Testing System (IELTS) Academic Version and we require candidates to achieve the level of "GOOD".
  • Good level: Overall grade of 7.0 with a minimum of 6.5 in each of the subtests.

Candidates who are unsure if they meet the entry criteria should contact us before submitting an application.



Fully funded places include home (UK/EU) tuition fees and a tax-free stipend in the region of £16,777.

EU applicants must meet the UKRI Residency Criteria to be eligible for full funding. Candidates should refer to the The Education (Fees and Awards) (England) Regulations 2007 for more details

Applicants who are applying for DTP places but who are not eligible for fully funded BBSRC studentships may be eligible for fully funded (Home/EU Fees only) Institutional Studentships.

More details are available by contacting the programme administration.