Defining the mechanism of host cell exit by Chlamydia trachomatis

Abstract

A molecular understanding of bacterial disease is critical for the development of novel diagnostics and therapeutics, particularly given the increasing incidence of antibiotic resistance. Such studies also illuminate fundamental cellular mechanisms. The intracellular pathogen Chlamydia trachomatis replicates within a specialised compartment (inclusion), which is segregated from the endocytic pathway yet intercepts secretory traffic and engages organelles. The inclusion is extruded at the end of the replication cycle, but how this occurs remains unknown. Building on preliminary data, the project will investigate host and bacterial factors involved in chlamydial exit.





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Biological Areas:

Cell Biology
Microbiology

BBSRC Area:

Molecules, cells and industrial biotechnology