Development of a platform for isolation and propagation of single circulating cancer stem cells from the blood of cancer patients

Abstract

In our previous works, we identified metastatic cancer stem cells (CSCs) as the most aggressive subset of CSCs that can also be found in the circulating blood. Herein, we seek to develop advanced technology to efficiently isolate and propagate single tumorigenic CSCs from the circulating blood from cancer patients, thereby targeting a major milestone in establishing the future CSC-centred therapeutics. Novel nano-volume well plates from our preliminary work for expanding single CSCs, will be advanced by the creation and tight control of more complex, biomimetic, and tuneable three-dimensional (3D) environments to propagate these extremely rare circulating cells at high fidelity.





References:
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Biological Areas:

Cell Biology
Biotechnology

BBSRC Area:

Molecules, cells and industrial biotechnology