Exovesicle formation in Porphyromonas gingivalis

Abstract

Gram -ve bacteria shed vesicles from their outer membranes as part of their interactions with eurkarotic hosts. It is clear from previous research that this is an ordered process, with only a subset of proteins being packaged in vesicles. This project aims to understand the molecular basis for the vesicle formation in the dental pathogen Porphyromonas gingivalis and to understand how the selective loading of vesicles is achieved. This project will use molecular microbiology coupled with fluorescent microscopy and electron microscopy to unravel this process and shed light on the biology of the bacterial outer membrane.





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Biological Areas:

Cell Biology

BBSRC Area:

Plants, microbes, food and sustainability