The mechanical control of tissue regeneration

Abstract

Tissue repair and regeneration after wounding is a fundamental problem of vast medical importance. Previous studies have largely focused on the biochemical and genetic control of tissue regeneration. However, there is increasing evidence that the mechanical environment of the tissue also plays a role in the regeneration process. The project will use an interdisciplinary approach to understand how tissue mechanics contributes to regeneration, and importantly, how the tissue senses when to stop healing - a problem that has been largely neglected to-date.





References:
[1]

Mao Y, Tournier AL, Hoppe A, Kester L, Thompson BJ, Tapon N. (2013) Differential proliferation rates generate patterns of mechanical tension that orient tissue growth. EMBO J. 2013 Oct 30;32(21):2790-803

[2]

Mao Y, Tournier AL, Bates PA, Gale JE, Tapon N, Thompson BJ. (2011) Planar polarization of the atypical myosin Dachs orients cell divisions in Drosophila. Genes & Dev. 2011 Jan 15;25(2):131-6. Highlighted as “Must read” by Faculty of 1000.

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Repiso A, Bergantiños C, Corominas M, Serras F. (2011) Tissue repair and regeneration in Drosophila imaginal discs. Dev Growth Differ. 2011 Feb;53(2):177-85.

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Shipley RJ, Chapman SJ.(2010). Multiscale modelling of fluid and drug transport in vascular tumours. Bull Math Biol. 2010 Aug;72(6):1464-91.

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Shraiman BI. (2005) Mechanical feedback as a possible regulator of tissue growth. Proc Natl Acad Sci U S A. 2005 Mar 1;102(9):3318-23.


Biological Areas:

Development
Genetics

BBSRC Area:

Genes, development and STEM approaches to biology