Sleep in Zebrafish Models of Neurodevelopmental Disorders


Although neurodevelopmental disorders such as autism and schizophrenia are associated with disrupted sleep, the extent to which sleep-regulating circuits are disrupted by these diseases is unknown. Similarly, it is unclear how altered sleep influences disease progression and symptoms. The combination of new genome editing techniques with advances in neuronal imaging and behavioral pharmacology makes the larval zebrafish an excellent model system to investigate normal and mutant sleep circuits. This project will generate zebrafish harboring mutations in neurodevelopmental disease genes, assess a series of normal and drug-induced sleep and locomotor phenotypes, and examine developmental changes to sleep circuits.


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Genes, development and STEM approaches to biology