The effect of rapamycin loaded nanoparticles on the extension of lifespan in laboratory model organisms

Abstract

The aim is to improve delivery of the drug rapamycin, which promotes health during ageing in multiple organisms including mammals. The student will develop and characterise the nanocarrier system encapsulating rapamycin using nanospray drying, scanning electron microscopy, laser diffraction particle sizing and in vitro drug release. The viability and proliferation of cells grown with the new rapamycin nanoformulation will be studied. Finally, survival and function during ageing of fruit flies exposed to the nanoformulation will be examined, along with measurement of drug efficacy, and in vivo drug absorption following administration of new rapamycin nanoformulation to aged rodents will be assessed.





References:
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Biological Areas:

Ageing

BBSRC Area:

Molecules, cells and industrial biotechnology