Kinesins are a superfamily of microtubule-based nanomotors that use their ATPase activity to produce force. A number of different kinesins perform essential functions in the nervous system. Nerve cells exhibit a highly polarised and compartmentalised structure including axon and somatodendritic compartment. This polarity is critical for neuronal development, function, signalling and information processing. The mechanisms that underpin the development of neuronal polarity and the polarised targeting of cargo within neurons however remain poorly understood. This project proposes to investigate the role of a poorly characterised brain specific kinesin motor protein (KIF21B) for neuronal polarity and connectivity.
Twelvetrees AE, Yuen EY, Arancibia-Carcamo IL, Rostaing P, Lumb MJ, Triller A, Saudou F, Yan Z, Kittler JT (2010) Delivery of GABAA receptors to synapses is mediated by HAP1-KIF5 and disrupted by mutant huntingtin. Neuron. 65:53-65.
The structural basis of force generation by the mitotic motor kinesin-5. Goulet A, Behnke-Parks WM, Sindelar CV, Major J, Rosenfeld SS, Moores CA (2012) J. Biol. Chem. 287, 44654-66.
Insight into the molecular mechanism of the multi-tasking kinesin-8 motor. Peters C, Brejc K, Belmont L, Bodey A, Lee Y, Yu M, Guo J, Sakowicz R, Hartman J, Moores CA (2010) EMBO J. 29:3437-3447
Smith KR, Muir J, Rao Y, Browarski M, Gruenig MC, Sheehan DF, Haucke V, Kittler JT (2012) Stabilization of GABA(A) receptors at endocytic zones is mediated by an AP2 binding motif within the GABA(A) receptor beta 3 subunit. J Neurosci. 32:2485-98.