Polycomb proteins modify chromatin to maintain developmental regulator genes specific for other cell types in a repressed state and are essential for cell differentiation. How polycomb proteins are targeted to specific genes is unclear but this information is key to understanding how how cell identity is controlled. Unexpectedly, non-coding RNAs have emerged as key players in chromatin regulation and we have recently identified the set of RNAs that directly interact with polycomb repressive complex 2 (PRC2) in ES cells. The PhD project will combine genomics and developmental biology techniques to identify the mechanism through which these RNAs act.
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