Taking control of synthetic biology – optimizing the design and construction of robust regulatory circuits.

Abstract

Synthetic biology aims to engineer organisms to perform useful medical or industrial functions. To control these functions, gene circuits will be required that can operate reliably in environments that are noisy, changing over time and subject to sometimes poorly defined interactions with the host cell. Therefore designing dependable gene circuits that can function safely over a wide range of conditions is paramount to the successful development of all synthetic biological applications. For example this might include the safe, controlled delivery of novel therapeutics in the human gut or release of toxins to destroy disease vectors only when they become hosts.





References:
[1]

Barnes CP, Silk D, Sheng X, Stumpf MP, Bayesian design of synthetic biological systems, Proc Natl Acad Sci U S A. 2011 Sep 13;108(37):15190-5.

[2]

Barnes CP, Silk D, Stumpf MP, Bayesian design strategies for synthetic biology, Interface Focus. 2011 Dec 6; 1 (6) 886-894;

[3]

Engler C, Kandzia R and Marillonnet S, PLoS One 2008, 3(11), e3647.

[4]

Gibson DG, Young L, Chuang R-Y, Venter JC, Hutchison CA, Smith HO Nature Methods 2009, 6(5), 343-345


Biological Areas:

Cell Biology
Biotechnology

BBSRC Area:

Genes, development and STEM approaches to biology
Molecules, cells and industrial biotechnology