Identification and characterisation of anti-leishmanial drug efficacy determinants

Abstract

Leishmania spp cause a range of devastating diseases endemic throughout the Tropics and sub-Tropics; the available drugs are limited in their efficacy and selectivity, and resistance is a developing problem (1). Apart from AQP1-mediated sodium stibogluconate (SSG) resistance, little is known about the uptake and intracellular transit of the four anti-Leishmania drugs. Identifying these efficacy determinants will highlight potential routes to resistance, help to define the modes of action of these drugs, and has the potential to inform the development of novel interventions.





References:
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Berg M, Mannaert A, Vanaerschot M, Van Der Auwera G, Dujardin JC. (2013) (Post-) Genomic approaches to tackle drug resistance in Leishmania. Parasitology 140:1492-505

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Biological Areas:

Cell Biology
Microbiology

BBSRC Area:

Animal disease, health and welfare