Stem cells in motion: Analysis of embryonic cell-to-tissue morphogenesis

Abstract

Using stem cells to regenerate tissues requires that we know how tissues are built up in normal development. We have previously shown that tissue growth – specifically elongation – involves not just proliferation but also cell shape change and rearrangement. To understand these processes better, this project is to analyse the self-organisation of cell aggregates both in vivo and in silico. This is a form of synthetic biology at the cellular level.





References:
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3. Ninomiya H., Winklbauer R. (2008). Epithelial coating controls mesenchymal shape change through tissue-positioning effects and reduction of surface-minimizing tension. Nat. Cell Biol. 10, 61-69.

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4. Hopyan S, Sharpe J, Yang Y. (2011) Budding behaviors: Growth of the limb as a model of morphogenesis. Developmental Dynamics. 240(5):1054-62.


Biological Areas:

Cell Biology
Development

BBSRC Area:

Genes, development and STEM approaches to biology