Using Next Generation Sequencing to investigate canine B cell lymphoma: therapeutic implications for dogs and canine models for non-Hodgkin lymphoma

Abstract

A heterogeneous regulatory population of cells, including regulatory T cells and myeloid-derived suppressor cells, shapes the cancer microenvironment. Prof. Oliver Garden at the Royal Veterinary College and collaborators are using Next Generation Sequencing (NGS) to characterise the cellular/molecular phenotypes and functional interactions associated with canine B cell lymphoma (BCL) as a prelude to their manipulation for therapeutic purposes. The aim of this PhD project is to develop computational methods to enrich the analysis of this BCL data, including techniques that facilitate cross-species meta-analyses for evaluating the suitability of mammalian models for immunological and oncological research.





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Biological Areas:

Cell Biology
Immunology

BBSRC Area:

Animal disease, health and welfare