Probing the Mechanism of Gating in Sodium Channels by Experiment and Computation

Abstract

Voltage-gated Na+-channels are transmembrane proteins that are responsible for the fast depolarizing phase of the action potential in nerve and muscular cells. In humans, mutations in these channels cause a wide rang of cardiovascular and neurological diseases. This project will entail both experimental techniques (molecular biology, biochemistry, crystallography) and computational methods (Molecular dynamics simulations and bioinformatics) to investigate the structure/function relationships, especially the permeation and gating processes, for voltage-gated sodium channels. 





References:
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Biological Areas:

Development
Genetics

BBSRC Area:

Genes, development and STEM approaches to biology