Investigation of gene regulatory interactions that control cell fate decisions in the developing heart.

Abstract

Endothelial cells of the heart, the endocardium, are required for myocardial differentiation, ventricular septation, valve formation and later stages of ventricular morphogenesis. Identification of the gene networks that specify endocardial cell differentiation is crucial for understanding mammalian heart development. This project aims to identify the long-range regulatory interactions that underlie endocardial gene expression. Using newly developed methodologies, the student will generate genome-wide promoter interaction libraries from endocardial and endothelial cells. Bioinformatics analyses will identify the interactions to regulatory elements such as enhancers that underlie transcriptional differences between these cell types, to better understand the processes of cellular differentiation.





References:
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Biological Areas:

Development
Genetics

BBSRC Area:

Genes, development and STEM approaches to biology