Division requires the precise segregation of the entire set of cellular structures. Despite this, studies of eukaryotic cell division have tended to focus on chromosomes segregation, while almost nothing is known about the way the ER is segregated at division. The aim of this project is to use advanced imaging technologies and biophysical techniques to remedy this to understand how the endoplasmic reticulum is properly formed and distributed between daughter cells during mitosis and divisions.
Rodrigues NTL, Lekomtsev S, Jananji S, Kriston-Vizi J, Hickson GRX and Baum B. Kinetochore-localized PP1/Sds22 couples chromosome segregation to polar relaxation. Nature (2015) in press
Carlton J, The ESCRT-machinery, a cellular apparatus for sorting and scission, Biochem Soc Trans (2010) 38:1397.
Olmos Y, Hodgson L, Mantell J, Verkade P and Carlton JG. ESCRT-III controls nuclear envelope reformation, Nature (2015), in press
Baum DA, Baum B. An inside-out origin for the eukaryotic cell. BMC Biology (2014) 12:76
Dugina et al., β- and γ-cytoplasmic actins display distinct distribution and functional diversity, J Cell Sci (2009) 122:2980