Visualizing real-time membrane protein motions in lipid membranes by mass spectrometry


Membrane transport proteins are ubiquitous integral membrane proteins critical to many important biological processes. Current depictions of membrane transport describe a process in which dynamic changes in protein structure facilitate the passage of small molecules through lipid membranes. The present challenge is to understand how these structural changes operate in concert, on both the local and global level, to orchestrate membrane transport and how these dynamic motions vary according to the local environment. This will require the development of state-of-the-art tools capable of capturing the dynamics of membrane proteins in real time and reporting them at high resolution.


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Biological Areas:

Structural Biology
Chemical Biology


Molecules, cells and industrial biotechnology