Small molecules that bend lipid membranes: towards a self-motile, chemotactic nano-containers

Abstract

In this project we will study how lipid membrane shape can be manipulated by the coordinated action of small molecules and will apply the knowledge gathered towards the development of chemotactic artificial cell-mimetic constructs. Such constructs will have the potential of being develop in drug carriers and targeted drug delivery vehicles





References:
[1]

" Modulation of In-Membrane Receptor Clustering upon Binding of Multivalent Ligands". A. Grochmal, E. Ferrero, L. Milanesi and S.Tomas J Am. Chem. Soc. 2013, 135 , 10172

[2]

"Mutual Modulation between Embedded Receptor Clustering and Ligand Binding in Lipid Membranes". S.Tomas, L. Milanesi, Nature Chem. 2010, 2, 1077

[3]

"Hydrophobically self-assembled nanoparticles as molecular receptors in water".S. Tomas and L. Milanesi, J. Am. Chem. Soc. 2009, 131, 6618.

[4]

“Membrane Fission Is Promoted by Insertion of Amphipathic Helices and Is Restricted by Crescent BAR Domains”. E. Boucrot, A. Pick, G. Camdere, G, N. Liska, E. Evergren, H.T. McMahon, M. M. Kozlov Cell 2012, 149, 124


Biological Areas:

Chemical Biology
Biotechnology

BBSRC Area:

Molecules, cells and industrial biotechnology