Role for the cross-talk between focal adhesion-TGF beta signalling in activating cellular senescence and ageing


Cellular senescence is a process by which primary cells detect a stress signal, stop replicating and modify their surrounding microenvironment1,2. The accumulation of senescent cells contributes to organismal ageing3, but the precise mechanisms regulating this process are not well understood. Our lab has recently described the need for the interaction of focal adhesion (FA) with the extracellular matrix (ECM) regulating senescence and ageing, by activating the TGFb pathway4. However, the mechanisms implicated, the impact throughout ageing and the discovery of therapeutic targets to tackle senescent cells regulating FA, have not been addressed.


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Muñoz-Espín, D. and Serrano, M. (2014) Cellular senescence: from physiology to pathology. Nat. Rev. Mol. Cell Biol. 15, 482–96


Baker, D.J. et al. (2016) Naturally occurring p16Ink4a-positive cells shorten healthy lifespan. Nature DOI: 10.1038/nature16932


Rapisarda et al. (2016) Integrin beta 3 regulates cellular senescence and ageing. Submitted to Cell Reports


Hosny, N.A. et al. (2013) Super-Resolution Imaging Strategies for Cell Biologists Using a Spinning Disk Microscope. PLoS One 8,

Biological Areas:

Cell Biology


Animal disease, health and welfare