The focus of this project is to create a novel bioelectronic platform for electrophysiological measurements in cardiac myocytes. Specific grafting of relevant biomolecules to electroactive organic materials will facilitate measurements of the cellular response in defined environments. The development of a modular platform for grafting a wide array of specific biomolecules ranging from small peptides to large proteins onto organic electronic materials will drive the project from proof-of-principle to complex platforms in follow up studies, where tailor-made bioelectronic materials will be used to mimic cellular niches or to produce conductive nanopillar arrays to combine force and electrophysiology measurements.
Iskratsch, T., Wolfenson, H. & Sheetz, M.P. Appreciating force and shape: the rise of mechanotransduction in cell biology. Nature Reviews Molecular Cell Biology 15, 825-33 (2014)
Wolfenson, H., Meacci, G., Liu, S., Stachowiak, M., Iskratsch, T., et al. Tropomyosin controls sarcomere-like contractions for rigidity sensing and suppressing growth on soft matrices. Nature Cell Biology 18, 33-42 (2016).
Giovannitti, A., Nielsen, C. B., Rivnay, J., Kirkus, M., Harkin, D. J., White, A. J. P., Sirringhaus, H., Malliaras, G. G., McCulloch, I. Sodium and Potassium Ion Selective Conjugated Polymers for Optical Ion Detection in Solution and Solid State. Advanced Functional Materials 26, 514-23 (2016)