There is now compelling evidence that senescence drives ageing. Senescent cells secret inflammatory molecules collectively called the senescence-associated secretory phenotype (SASP). We now appreciate different senescent triggers can lead to a varied SASP composition, however, the SASP of senescent cancer cells remains virtually unexplored.
Our group have established a panel of triggers that induce senescence in normal and cancer cells including modulation of a subset of ribosomal proteins. We will determine the different SASP cocktails induced by these triggers isolating novel drivers of paracrine senescence, profile the senescent ribosome, and determining the translatome of senescent normal and cancer cells.
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