Uncovering the mechanism of senescence activation in cancer cells


There is now compelling evidence that senescence drives ageing. Senescent cells secret inflammatory molecules collectively called the senescence-associated secretory phenotype (SASP). We now appreciate different senescent triggers can lead to a varied SASP composition, however, the SASP of senescent cancer cells remains virtually unexplored.

Our group have established a panel of triggers that induce senescence in normal and cancer cells including modulation of a subset of ribosomal proteins. We will determine the different SASP cocktails induced by these triggers isolating novel drivers of paracrine senescence, profile the senescent ribosome, and determining the translatome of senescent normal and cancer cells.


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Ingolia, N.T., L.F. Lareau, and J.S. Weissman, Ribosome profiling of mouse embryonic stem cells reveals the complexity and dynamics of mammalian proteomes. Cell, 2011. 147(4): p. 789-802.

Biological Areas:

Cell Biology


Genes, development and STEM approaches to biology