TRANSLATIONAL STUDY OF THE MODULATORY INFLUENCE OF THE AUTONOMIC NERVOUS SYSTEM ON STRESS INDUCED ACTIVATION OF THE IMMUNE SYSTEM 

Abstract

Stress activates the immune system, Hypothalamic Pituitary Adrenal (HPA) axis and the Autonomic Nervous System (ANS) with inter-individual differences. Preliminary, animal and human studies suggest that the parasympathetic branch of the ANS (vagus-nerve) is anti-inflammatory and reduces activity of the stress response. Recent innovations allow non-invasive trans-cutaneous Vagal (Nerve) Stimulation (t-VNS) in humans. Students will use validated methods in both rodents and health humans before and after administration of vagal stimulation to determine if stress response systems can be modulated and study reasons for inter-individual differences. This work has implications for treatment of chronic stress related disorders and inflammatory diseases.  




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Biological Areas:

Neurobiology
Immunology

BBSRC Area:

Animal disease, health and welfare
Plants, microbes, food and sustainability
Genes, development and STEM approaches to biology