Antiviral restriction factors are host cellular proteins that directly inhibit viral replication and their expression is typically interferon inducible. Restriction factors also regulate endogenous retroelements present in the host genome due to their functional and evolutionary similarities with exogenous retroviruses. Recent screening studies have revealed a number of novel interferon stimulated gene (ISG) candidates encoding antiviral restriction factors that can negatively regulate human LINE-1 retrotransposon mobility. The aim of this project is to use a mix of bioinformatic and molecular analysis to understand how candidate ISGs aid endogenous retroelement control.
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