Unravelling the Interstrand Crosslinking DNA Repair Systems of Trypanosoma cruzi

Abstract

All living cells are subject to agents that promote DNA damage. A particularly lethal lesion are interstrand crosslinks (ICL), a property exploited by several anti-cancer chemotherapies. In yeast and humans enzymes that play key roles in repairing such damage include the nucleases SNM1, MRE11, FAN1 and EXO1. In this project, we plan to evaluate the function of the homologues expressed by Trypanosoma cruzi, the causative agent of Chagas disease, with the aim of determining their role and importance to this parasite.




References:
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Biological Areas:

Cell Biology
Microbiology

BBSRC Area:

Molecules, cells and industrial biotechnology