Retroviruses have infected mammals for >100 million years, leaving descendants in host genomes known as endogenous retroviruses (ERVs). Retrovirus activity differs widely among species: in humans, most ERV lineages are inactive, whereas in mice they are active. Newly published mammal genomes provide new opportunities to study ERV features in a comparative framework. This BBSRC-PhD project specifically aims to understand the host biological and ecological factors that determine ERV success. The student will focus on bats, which harbour numerous viruses of public health concern, and for which there are already >10 genomes available, with more due to be released soon.
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Dr?gan M, Moghul I, Priyam A, Bustos C & Wurm Y (2016) GeneValidator: identify problems with protein-coding gene predictions. Bioinformatics doi: 10.1093/bioinformatics/btw015