The developmental programming hypothesis posits that environmental insults in utero can have a major influence on adult-onset disease and phenotypic outcomes. We are interested in understanding the mechanistic basis of this phenomenon in mammals. In particular, identifying developmental programming-induced molecular perturbations, such as epigenetic marks, and then understanding how these perturbations influence phenotype. The project will be highly inter-disciplinary and will involve novel in vitro assays, followed by translation into a unique long-standing human cohort from the Gambia. The experimental work will be underpinned by bioinformatics/statistical analyses of (epi)genome-scale datasets.
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Holland et al. (2016) Gene-environment induced epigenetic dynamics at rDNA in the mouse. Science (in press)