The project will investigate the how Leishmania use their secreted and surface phosphoglycans and exploit components of the host bloodmeal to colonise their sand fly vector for efficient transmission.
Sacks DL, Kamhawi S. (2001). Molecular aspects of parasite-vector and vector-host interactions in leishmaniasis. Annu Rev Microbiol 55, 453–483.
Kamhawi S, Ramalho-Ortigao M, Pham VM, Kumar S, Lawyer PG, Turco SJ, Barillas-Mury C, Sacks DL, Valenzuela JG. (2004). A role for insect galectins in parasite survival. Cell. 119: 329-341.
Myskova, J., Svobodova, M, Beverley, S.M., Volf, P. (2007). A lipophosphoglycan-independent development of Leishmania in permissive sand flies. Microbes Infect 9, 317-324.
Rogers ME, Ilg T, Nikolaev AV, Ferguson MA, Bates PA. (2004). Transmission of cutaneous leishmaniasis by sand flies is enhanced by regurgitation of fPPG. Nature 430: 463-467.
Rogers ME. (2012). The role of Leishmania proteophosphoglycans in sand fly transmission and infection of the mammalian host. Front. Microbiol. 3: 223.