Mycobacterium bovis causes tuberculosis (TB) in domestic cattle and, in the UK, control of bovine TB is estimated to cost £100M annually. Currently there is no effective vaccine and those based on Mycobacterium bovis BCG, the vaccine licensed for use against human TB, shows limited efficacy. This project will identify and verify genes essential for survival of M. bovis in vivo thereby providing novel vaccine candidates with the potential to contribute to more cost-effective control programs.
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