Design, synthesis, and characterisation of novel peptide bio-surfactants

Abstract

Peptide bio-surfactants based on pancreatic polypeptide hormone will be engineered for use in the formulation of personal care products and pharmaceuticals. The peptides will be designed via computer-aided molecular modeling, and then synthesized using solid phase techniques. Their 3D structures will be studied using circular dichroism and nuclear magnetic resonance spectroscopy, and their interfacial properties investigated using a combination of small angle scattering, surface tensiometry and reflectivity measurements.




References:
[1]

Ren, Q., Kwan, A. H. and Sunde, M. Two Forms and Two Faces, Multiple States and Multiple Uses: Properties and Applications of the Self-Assembling Fungal Hydrophobins. Peptide Sci. 100, 601 – 612 (2013).

[2]

Germain, N., Minnion, J. S., Tan, T., Shillito, J., Gibbard, C., Ghatei, M. and Bloom, S. Analogs of pancreatic polypeptide and peptide YY with a locked PP-fold structure are biologically active. Peptides 39, 6 – 10 (2013).

[3]

Molecular Operating Environment (MOE), 2013.08; Chemical Computing Group Inc., 1010 Sherbooke St. West, Suite #910, Montreal, QC, Canada, H3A 2R7, 2016.


Biological Areas:

Structural Biology
Chemical Biology

BBSRC Area:

Molecules, cells and industrial biotechnology