The microbiome is involved in human metabolism, nutrition, physiology, and immune function therefore associated with both health and disease1. Among human microbiome populations, saliva’s microbiome provides a powerful non-invasive option for developing biomarkers describing health and disease. Our aim is to use novel statistical integrative approaches while combining host (mRNA) and microbiome (mRNA and DNA) saliva-derived profiles to identify novel non-invasive biomarkers. In this project we will functionally characterize the salivary microbiome in healthy individuals based on age and diet; secondly, we will challenge the ability of saliva’s microbiome to describe health by comparing to individuals with chronic intestinal disease.
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