Fungi and their role in the oral microbiome

Abstract

The last decade saw an exponential increase in interest in human microbial communities1. These communities impact both healthy and diseased hosts, with associations to nutrition, development and inflammatory disease. Although research has identified many species of bacteria in the oral cavity, fungal constituents are poorly characterised, despite their undoubted presence.  Further, the interactions between fungi and bacteria in these communities is unclear. This study aims to characterise the fungi present in the oral cavity and describe their interactions with the bacteria in these niches, determining how these interactions help shape microbial communities and identify potential novel antimicrobial compounds.




References:
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Ghannoum, M. A. et al. Characterization of the oral fungal microbiome (mycobiome) in healthy individuals. PLoS pathogens 6, e1000713, (2010).

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Mukherjee, P. K. et al. Oral mycobiome analysis of HIV-infected patients: identification of Pichia as an antagonist of opportunistic fungi. PLoS pathogens 10, e1003996, (2014).

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Moyes, D. L. & Naglik, J. R. The mycobiome: influencing IBD severity. Cell Host Microbe 11, 551-552, (2012).

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Biological Areas:

Microbiology
Genetics

BBSRC Area:

Plants, microbes, food and sustainability