Cell membranes are composed of different lipid phases, which regulate the diffusion and clustering of membrane molecules – with important implications in health and disease. Membrane phase is often studies using phase-sensitive fluorescent membrane probes together with fluorescence spectroscopy and microscopy. This project will combine these techniques with atomistic scale molecular dynamics simulations in artificial membranes and cells. In this way, we will establish the relationship between the local physical properties actually sensed by the probes and the macro-scale molecular outcomes of interest in the biological sciences.
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