Well-defined, modifiable hydrogel networks to unravel key parameters that control stem cell fate in 3D  

Abstract

Tissue engineering (TE) has the potential to treat many medical conditions, but is hampered by a limited understanding of how the physical characteristics of a cell’s 3D niche direct its differentiation. The aim of this project is to engineer a platform system of novel, well-defined modular hydrogels to determine the key physical parameters that drive stem cell fate in 3D. We will design, synthesise and characterise well-defined 3D gels with systematically varied structural and mechanical characteristics. We will then encapsulate human mesenchymal stem cells within the gels and monitor their differentiation using a combination of histological and molecular biology techniques. 




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Biological Areas:

Cell Biology
Biotechnology

BBSRC Area:

Genes, development and STEM approaches to biology