The great challenge of research into ageing rests in the need of truly predictive biomarkers that can mark the health status and characterize effective modulations without the wait for the whole ageing trajectory.
The key observation inherited from the third law of physics is that organs, systems and subjects do not go through time in the same way but age differently and that this process is driven by diverse rates of entropy.
Hence, using EEG and fMRI data we will develop instantaneous estimators of chronological brain age using entropy estimators that will be validated by ancillary measures of mitochondrial efficiency.
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