Bacterial Protein Glycosylation: Exploring a New Frontier in Microbiology

Abstract

Infectious diseases remain the leading cause of death worldwide. With bacterial resistance on the rise, a deeper understanding of the fundamental biology of bacteria is essential. Protein glycosylation systems have recently been identified in virtually all bacterial pathogens, yet remain a largely unexplored frontier in microbial science. In this project, we are developing enzyme inhibitors for a key step in bacterial protein N-glycosylation. The new inhibitors will be powerful tools to study the interplay of protein glycosylation and virulence in respiratory pathogens such as Haemophilus influenzae, and a potential starting point for the development of a new class of “glycobiotics”.




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Biological Areas:

Chemical Biology
Microbiology

BBSRC Area:

Plants, microbes, food and sustainability