How do tissues sense and respond to the changing shape of the growing embryo? We address this in the zebrafish neural tube roof plate; a squamous epithelium of single cell thickness composed of polygonal cells in a tensioned lattice. Time-lapse imaging in wildtype and mutant zebrafish using cutting edge confocal microscopy and computational models of deformable lattices with different morphological properties will be used. We will test the hypothesis that epithelial growth and shape is integrated with surrounding tissue morphogenesis via tension driven lattice plasticity. Lattice plasticity operates through a combination of cell division, cell shape change and cell extrusion
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