Assessment of Endothelial Function by Non-Invasive Arterial Pulse Wave Analysis


Dysfunction of endothelial cells lining blood vessels is a major risk factor for cardiovascular disease. This project will investigate a new non-invasive technique to assess endothelial function by analysis of the arterial pulse wave. Pulse waveform changes produced by pharmacological drugs that alter endothelial function will be studied in the rabbit and mouse. A computational biophysical model of blood flow in the rabbit cardiovascular system will be developed, validated and applied to identify the haemodynamic mechanisms underlying these changes and determine whether endothelial dysfunction alone is their primary cause. In the last year, the technique will be tested in humans.


Chowienczyk P, Kelly R, MacCallum H, Millasseau S, Andersson T, Gosling R, Ritte J, Ängga?rd E. Photoplethysmographic assessment of pulse wave reflection: blunted response to endothelium-dependent beta2-adrenergic vasodilation in type II diabetes mellitus. J Am Col Cardiol 34(7):2007-14, 1999 (PubMed ID: 10588217).


Weinberg P, Habens F, Kengatharan M, Barnes S, Matz J, Ängga?rd E, Carrier M. Characteristics of the pulse waveform during altered nitric oxide synthesis in the rabbit. British J Pharm 133(3):361-70, 2001 (PubMed ID: 11375252).


Alastruey J, Nagel S, Nier B, Hunt A, Weinberg P, Peiro J. Modelling pulse wave propagation in the rabbit systemic circulation to assess the effects of altered nitric oxide synthesis. J Biomech 42(13):2116-23, 2009 (PubMed ID: 19646697).


Willemet M, Alastruey J. Arterial pressure and flow wave analysis using time-domain 1-D hemodynamics. Ann Biomed Eng 43(1):190-206, 2015 (PubMed ID: 25138163).


Aston P, Nandi M, Christie M, Huang Y. Comparison of attractor reconstruction and HRV methods for analysing blood pressure data. IEEE Comput Cardiol 41:437-440, 2014.

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