Molecular characterisation of Candidalysin-epithelial membrane interactions


Candidalysin is a newly-discovered cytolytic peptide toxin that is secreted by the fungal pathogen Candida albicans [1], the causative agent of thrush which causes millions of mucosal infections annually [2]. Candidalysin is essential for the ability of C. albicans to activate epithelial cells and induce cell damage, and is critical for mucosal pathogenicity in vivo [1, 3, 4]. This landmark discovery represents a seminal advance in our understanding of fungal pathogenesis. This project aims to build on these discoveries to identify the key membrane components that Candidalysin interacts with in order to damage and activate epithelial cells.


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Biological Areas:

Chemical Biology


Plants, microbes, food and sustainability