Proteins are subject to molecular wear and tear, in part through spontaneous modifications of their backbones that occur on the timescales of minutes to years. These processes contribute to ageing by damaging affected proteins, but emerging evidence suggests that backbone modifications also serve to regulate key cellular pathways such as apoptosis. This interdisciplinary PhD project aims to combine synthetic protein chemistry (Mueller lab), biophysics (Mueller and Eggert labs) and cell biology (Eggert lab) to elucidate the mechanistic aspects of how the tumor suppressor protein p53 is regulated by age.
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