Chemical Biology of Protein Ageing

Abstract

Proteins are subject to molecular wear and tear, in part through spontaneous modifications of their backbones that occur on the timescales of minutes to years. These processes contribute to ageing by damaging affected proteins, but emerging evidence suggests that backbone modifications also serve to regulate key cellular pathways such as apoptosis. This interdisciplinary PhD project aims to combine synthetic protein chemistry (Mueller lab), biophysics (Mueller and Eggert labs) and cell biology (Eggert lab) to elucidate the mechanistic aspects of how the tumor suppressor protein p53 is regulated by age. 




References:
[1]

Robinson, NE and Robinson, AB. PNAS (2001) 98: 944.

[2]

Lee, J-C et al. Nature Communications (2012) 3: 927.

[3]

Kruse, J-P and Gu, W. Cell (2009) 137: 609.

[4]

Muir, T. Annual review of biochemistry (2003) 72: 249.

[5]

Müller, M and Muir, T. Chemical Reviews (2015) 115: 2296.


Biological Areas:

Cell Biology
Ageing

BBSRC Area:

Genes, development and STEM approaches to biology
Molecules, cells and industrial biotechnology