The nematode parasites of the genus Trichinella infect a wide variety of mammalian hosts including humans and livestock. The larvae migrate through the body, invading skeletal muscle fibres and transforming them to a new structure termed the “nurse cell”, allowing the survival of the larvae for the life time of the host. We have found that some components of the host immune response are able to impact on the development of the nurse cell, however, the detailed mechanisms involved in this process and the failure of the immune response to prevent establishment are still largely unknown.
Inflammatory phenotype of the nurse cell harboring Trichinella spp. Dabrowska M. Vet Parasitol. 2013 May 20;194(2-4):150-4.
Contrasting roles for IL-10 in protective immunity to different life cycle stages of intestinal nematode parasites. Helmby H, Grencis RK. Eur J Immunol. 2003 Sep;33(9):2382-90.
Immunity to Trichinella spiralis muscle infection. Fabre MV, Beiting DP, Bliss SK, Appleton JA. Vet Parasitol. 2009 Feb 23;159(3-4):245-8.
IL-18 regulates intestinal mastocytosis and Th2 cytokine production independently of IFN-gamma during Trichinella spiralis infection. Helmby H, Grencis RK. J Immunol. 2002 Sep 1;169(5):2553-60.
Non-invasive fluorescence imaging of small animals. Zelmer, A., and Ward, T.H. (2013) J. Microsc., Oct;252(1):8-15.