Remodelling of skeletal muscle cells by intracellular nematode pathogens of the genus Trichinella

Abstract

The nematode parasites of the genus Trichinella infect a wide variety of mammalian hosts including humans and livestock. The larvae migrate through the body, invading skeletal muscle fibres and transforming them to a new structure termed the “nurse cell”, allowing the survival of the larvae for the life time of the host. We have found that some components of the host immune response are able to impact on the development of the nurse cell, however, the detailed mechanisms involved in this process and the failure of the immune response to prevent establishment are still largely unknown. 

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References:
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Inflammatory phenotype of the nurse cell harboring Trichinella spp. Dabrowska M. Vet Parasitol. 2013 May 20;194(2-4):150-4. 

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Biological Areas:

Cell Biology
Immunology

BBSRC Area:

Molecules, cells and industrial biotechnology