Within the developing vertebrate neural tube, different types of neuron are specified in a stereotypical pattern. This pattern depends on the expression of a set of transcription factors by the secreted protein Sonic Hedgehog (Shh). The transcription factors form a regulatory network that determines the dynamics and patterns of gene expression
A systematic mechanistic understanding of this network remains elusive. To address this, we have generated RNA-seq and ChIP-seq data from neural cells in different states of the network. The aim of this project is to develop methods to analyse these data and to dissect the gene regulatory network.
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