A genomic and chemogenomic approach to the protein quality control problem

Abstract

Protein quality control is vital to cellular health. Defects in protein quality control underlie a broad range of diseases, and are closely linked to the ageing process. The aim of this study is to describe the processes that regulate and modulate protein quality control at a systems-level and to identify new chemical modulators. The project will combine the genetic tractability of the yeast micromammal Schizosaccharomyces pombe with mammalian cell biology and a vertebrate zebrafish model, providing a highly detailed understanding of the networks and pathways that regulate this process, and new tools for its study.

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References:
[1]

Guo Y et al Genetics 2013 195:599-609

[2]

Gangadharan S et al Proc Natl Acad Sci USA 2010 107:21966-72

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Biological Areas:

Cell Biology
Genetics

BBSRC Area:

Genes, development and STEM approaches to biology