Study of the physical properties of cell-surface receptors in live cells via combined fluorescence microscopy and force sensing to improve our understanding of receptor-mediated virus entry.

Abstract

This project, at the interface of physics, engineering and biology, aims to combine ultrasensitive fluorescence-imaging detection with optical/magnetic force sensing, for investigating the mechanisms of receptor-mediated virus entry into cells.

Viral infections remain a serious threat to human health. For example, HIV-1 infects approximately two million people a year and kills a similar number. Viruses hijack fundamental cellular processes to replicate and cause infection. They exploit specific cell-surface receptors to penetrate the cell-membrane barrier of new host cells by mechanisms that are not well understood. These will be investigated applying novel biophysical approaches and using HIV-1 as an experimental model.

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References:
[1]

“The cell biology of receptor-mediated virus entry”, J. Grove and M. Marsh, J. Cell Biol. 195, 1071 (2011).


Biological Areas:

Cell Biology

BBSRC Area:

Animal disease, health and welfare