MRI monitoring of pancreatic islet cell transplants in vivo using biofunctionalized magnetic nanoparticles as contrast agent


Replacement of insulin production by islet transplantation has great potential as a therapy for type 1 diabetes. Determination of the functional dynamics of implanted islet cells in vivo is essential for the development and optimization of the islet therapies. In an effort to better understand mechanisms involved in graft functioning and rejection, we hope to develop methods using chemically modified polymer nanolayers for delivering novel iron oxide magnetic nanoparticles to track the engrafted islets by MRI imaging. The establishment of in vivo islet monitoring technique using MRI will assist us to understand their function, optimize their design, and predict their failure.

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