Large-scale phylogenomic mapping of domain architecture changes to elucidate gene function evolution


The sequencing revolution is transforming disease diagnosis, pathogen characterisation, and drugs development. However, sequencing alone is of limited use without methods to analyse and interpret these new data. Here, we will develop new methods to systematically identify domain architecture changes and infer where they occurred in terms of the evolutionary histories of the gene families involved. In this way, new links reflecting architecture changes will be established between as-of-yet disconnected orthologous groups. In turn, this will pave the route to improvements in protein function propagation and will provide a more comprehensive and integrated framework to study protein evolution across thousands of species.

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Rentzsch R, Orengo C a. 2009. Protein function prediction--the power of multiplicity. Trends Biotechnol. 27:210–219.


Altenhoff AM, Schneider A, Gonnet GH, Dessimoz C. 2011. OMA 2011: orthology inference among 1000 complete genomes. Nucleic Acids Res. 39:D289–94.


Sillitoe I, Cuff AL, Dessailly BH, et al. 2012. New functional families (FunFams) in CATH to improve the mapping of conserved functional sites to 3D structures. Nucleic Acids Res. 41:D490–8.


Altenhoff AM, Dessimoz C. 2012. Inferring Orthology and Paralogy. In: Anisimova M, editor. Vol. 855. Humana Press. p. 259–279.

Biological Areas:



Genes, development and STEM approaches to biology