Resolving Deep Animal Phylogeny Through Genome-wide Maximum Likelihood Phylogenetic Inference


Reconstructing accurate phylogenies is a major pursuit in biology, yet despite the progress made in our understanding of deep metazoan phylogeny, important questions remain. This interdisciplinary project will improve our ability to characterise and understand rapid radiation and rapid divergence. In the experimental part of the project, we will collect and sequence fresh material from multiple members of key taxa. In the computational part, we will implement a novel and efficient maximum likelihood tree inference method. The project could reveal the basis of aspects of evolutionary innovation important to the establishment of complex species.

ject details are protected. Please login with a valid account to view them.


Telford MJ, Copley RR (2011) Improving animal phylogenies with genomic data. Trends Genet 27: 186–195. doi:10.1016/j.tig.2011.02.003.


Philippe, H., Brinkmann, H., Copley, R,R,, Moroz, L,, Nakano, H,, Poustka, A,J,, Wallberg, A,, Peterson, K.J., and Telford, M.J. Acoelomorph flatworms are deuterostomes related to Xenoturbella Nature. 470:255-258.


Gribaldo S, Poole AM, Daubin V, Forterre P, Brochier-Armanet C (2010) The origin of eukaryotes and their relationship with the Archaea: are we at a phylogenomic impasse? Nature Reviews Microbiology 8: 743–752. doi:10.1038/nrmicro2426.


Holder MT, Zwickl DJ, Dessimoz C (2008) Evaluating the robustness of phylogenetic methods to among-site variability in substitution processes. Philos Trans R Soc Lond, B, Biol Sci 363: 4013–4021. doi:10.1098/rstb.2008.0162.


Altenhoff AM, Schneider A, Gonnet GH, Dessimoz C (2011) OMA 2011: orthology inference among 1000 complete genomes. Nucl Acids Res 39: D289–D294. doi:10.1093/nar/gkq1238.

Biological Areas:



Genes, development and STEM approaches to biology