Age is the most important risk factor for metabolic disorders such as obesity, type-2 diabetes and cancer. It is well established that reduced insulin signalling extends healthy lifespan of a number of organisms. The molecular effectors of this phenomenon are largely unknown.
Non–coding RNAs are important regulators of gene expression and cellular homeostasis. microRNAs, in particular, have emerged as important regulators of ageing. We will apply transcriptome analysis and bioinformatics to unravel the role of ncRNAs in the beneficial effects of insulin pathway down-regulation. The characterisation of ncRNA-regulated gene networks will reveal novel therapeutic targets in age-related metabolic decline.
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