ZIP14 (SLC39A14) is a transmembrane protein that belongs to the ZIP (SLC39) family of metal transporters. ZIP14 has been shown to mediate uptake of a variety of nutritionally important and essential divalent metals (zinc, iron and manganese). Dis-regulation of these metals has been associated with neurodegeneration, diabetes, cardiovascular, liver and kidney diseases as well as with ageing. This project will focus on the expression of ZIP14 isoforms in different tissue types to determine the precise intracellular localisation, functions and structure of ZIP14 isoforms in human cells.
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