Expression and function of metal transporter Zip14


ZIP14 (SLC39A14) is a transmembrane protein that belongs to the ZIP (SLC39) family of metal transporters. ZIP14 has been shown to mediate uptake of a variety of nutritionally important and essential divalent metals (zinc, iron and manganese). Dis-regulation of these metals has been associated with neurodegeneration, diabetes, cardiovascular, liver and kidney diseases as well as with ageing. This project will focus on the expression of ZIP14 isoforms in different tissue types to determine the precise intracellular localisation, functions and structure of ZIP14 isoforms in human cells.

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Pinilla-Tens JJ, Sparkman BK, Shawki A et al. (2011) Zip 14 is a complex broad-scope metal-ion transporter whose functional properties support roles in the cellular uptake of zinc and non-transferrin bound –iron. Am J Physiol Cell Physiol, 301:C862-71 


Nam H, Wang CY, Zhang W et al. (2013) Zip14 and DMT1 in the liver, pancreas, and heart are differentially regulated by iron deficiency and overload: implication for tissue iron uptakeand iron related disorders. Haematologica, 98:1049-57 98


Balesaria S, Hanif R, Salama MF , Raja K, Bayele HK, McArdle H, Srai SK. (2012) Fetal iron levels are regulated by maternal and fetal Hfe genotype and dietary iron. Haematologica, 97:661-9


Lawrence S P, Bright N A, Luzio J P and Bowers K. (2010). The sodium/ proton exchanger NHE8 regulates late endosomal morphology and function. Molecular Biology of the Cell, 21: 3540-3551


Al-Numair N.S. and Martin ACR. (2013) The SAAP pipeline and database: tools to analyse the impact and predictthe the pathogenicity of mutations. BMC Genomics!$ , 14:S4

Biological Areas:

Cell Biology


Molecules, cells and industrial biotechnology