Expression and function of metal transporter Zip14

Abstract

ZIP14 (SLC39A14) is a transmembrane protein that belongs to the ZIP (SLC39) family of metal transporters. ZIP14 has been shown to mediate uptake of a variety of nutritionally important and essential divalent metals (zinc, iron and manganese). Dis-regulation of these metals has been associated with neurodegeneration, diabetes, cardiovascular, liver and kidney diseases as well as with ageing. This project will focus on the expression of ZIP14 isoforms in different tissue types to determine the precise intracellular localisation, functions and structure of ZIP14 isoforms in human cells.

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References:
[1]

Pinilla-Tens JJ, Sparkman BK, Shawki A et al. (2011) Zip 14 is a complex broad-scope metal-ion transporter whose functional properties support roles in the cellular uptake of zinc and non-transferrin bound –iron. Am J Physiol Cell Physiol, 301:C862-71 

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Nam H, Wang CY, Zhang W et al. (2013) Zip14 and DMT1 in the liver, pancreas, and heart are differentially regulated by iron deficiency and overload: implication for tissue iron uptakeand iron related disorders. Haematologica, 98:1049-57 98

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Biological Areas:

Cell Biology
Genetics

BBSRC Area:

Molecules, cells and industrial biotechnology