Several neurodegenerative disorders, including Alzheimer’s disease, Parkinson’s disease, Huntington’s disease, and ALS share common features, most notably the accumulation of misfolded protein aggregates. The buildup of damaged protein inclusions results in activation of cellular stress responses emerging from the endoplasmic reticulum (ER). Recent findings place ER stress as a key component of neurodegeneration, highlighting the importance of understanding this signaling pathway. This project will combine multi-disciplinary approaches including high content cell-based screening, quantitative imaging, cell biological assays, and in vitro protein biochemistry to characterize the pathways that modulate and lead to neurodegeneration caused by protein misfolding and ER stress.
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