Routes to Tetrahydroisoquinolines using Synthetic Biology Approaches and Evolved Enzymes


This project aims to use norcoclaurine synthase native enzymes and mutants, together with other chemical or enzymatic steps (as synthetic biology pathways) to enable access to many diverse alkaloids with potential bioactivities. The project will pave the way for both natural and non-natural alkaloids to be synthesised in a sustainable fashion, cheaply and efficiently by biocatalysis in E. coli or other bacteria, under mild reactions conditions using renewable resources


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Biological Areas:



Molecules, cells and industrial biotechnology